English Name：Li Fangfang
中文名：李方方
Phone：010-62816620
Email：ffli@ippcaas.cn or elva1988@163.com
Web：https://www.researchgate.net/profile/Fangfang Li/publications
Academic Title：Professor
Supervisor：Master Supervisor, PhD Supervisor
Department：Department of Biotechnology in Plant Protection
Group：Plant-virus interaction

Education：

September 2009-June 2014: Ph.D. (Plant Virology), Zhejiang University, Hangzhou, China. My supervisors are Professor Xueping Zhou and Professor Zhenghe Li.

September 2005-June 2009: B.S. (Plant Protection), Nanjing Agricultural University, Nanjing, China (I was in the top 3% of all college students, and was recommended for a PhD fellowship without an exam). My mentor is Professor Fei Li.

Work Experience

August 2018- Current: Research Scientist Position (Plant-Virus Interaction Group), Institute of Plant Protection, Chinese Academy of Agricultural Sciences, China.  

May 2015- August 2018: Post doctoral Position (Plant Virology, Aiming Wang’s lab), Agriculture and Agri-Food, London, ON, Canada.

June 2014- May 2015: Post doctoral Position (Crop Genetics, Longjiang Fan’s lab), Zhejiang University, Hangzhou, China.

Areas of Specialization

(1) Dissection of RNA silencing pathway, RNA decay pathway, autophagy pathway, nuclear protein shuttle pathway, DNA methylation pathway, nicotine biosynthesis pathway, and many anti-viral pathways.

(2) Interaction between proteins and DNA/RNA/proteins.

(3) Dissection of replication and infection of Geminiviruses and Potyviruses.

(4) VIGS analyses in tobacco, tomato, soybean and cotton plants.

(5) Replication of Geminiviruses in yeast and in plants.

Representative Publications: (# co-first author, * co-corresponding author)

1. Fangfang Li and Aiming Wang*. RNA-Targeted Antiviral Immunity: More Than Just RNA Silencing. Trends in Microbiology. 2019. IF: 11.776. Cited by: 0
2. Fangfang Li *, Mingzhen Zhang, Changwei Zhang and Xueping Zhou. Nuclear autophagy degrades a geminivirus nuclear protein to restrict viral infection in Solanaceous plants. New Phytologist. 2019. IF: 7.299. Cited by: 0 (In publication)
3. Fangfang Li, Wende Liu and Xueping Zhou*. Pivoting plant immunity from theory to the field. Science China-Life Sciences. 2019. IF: 3.583 (In publication). Cited by: 0
4. Fangfang Li ^#, Xiongbiao Xu^#, Zhenghe Li, Yaqin Wang* and Xueping Zhou. Identification of Yeast Factors Involved in the Replication of Mungbean Yellow Mosaic India Virus Using Yeast Temperature-Sensitive Mutants. Virological sinca. 2019, 1-4. IF: 2.467. Cited by: 0
5. Fangfang Li, Changwei Zhang, Yinzi Li, Guanwei Wu, Xilin Hou, Xueping Zhou and Aiming Wang* Beclin1 restricts RNA virus infection in plants through suppression and degradation of the viral polymerase. Nature Communications. 2018, 9(1): 1268. IF: 12.124. Cited by: 20
6. Fangfang Li, Xiuling Yang, David M Bisaro and Xueping Zhou*. The βC1 Protein of Geminivirus–Betasatellite Complexes: A Target and Repressor of Host Defenses. Molecular Plant. 2018, 11: 1424-1426. IF: 9.326. Cited by: 3
7. Fangfang Li and Aiming Wang*. RNA decay is an antiviral defense in plants that is counteracted by viral RNA silencing suppressors. PLoS Pathogens. 2018, 148: e1007228. IF: 6.158. Cited by: 10
8. Fangfang Li, Nan Zhao, Zhenghe Li, Xiongbiao Xu, Yaqin Wang, Xiuling Yang, Shu-Sheng Liu, Aiming Wang and Xueping Zhou*. A calmodulin-like protein suppresses RNA silencing and promotes geminivirus infection by degrading SGS3 via the autophagy pathway in Nicotiana benthamiana. PLoS Pathogens. 2017, 13(2): e1006213. IF: 6.608. Cited by: 31
9. Fangfang Li, Changjun Huang, Zhenghe Li* and Xueping Zhou*. Suppression of RNA silencing by a plant DNA virus satellite requires a host calmodulin-like protein to repress RDR6 expression. PLoS Pathogens. 2014, 10: e1003921.IF: 8.057. Cited by: 92
10. Fangfang Li^#, Xiongbiao Xu^#, Changjun Huang, Zhouhang Gu, Linge Cao, Tao Hu, Ming Ding, Zhenghe Li* and Xueping Zhou*. The AC5 protein encoded by Mungbean yellow mosaic India virus is a pathogenicity determinant that suppresses RNA silencing‐based antiviral defenses. New Phytologist. 2015, 208(2): 555-569. IF: 7.672. Cited by: 33
11. Fangfang Li^#, Weidi Wang^#, Nan Zhao, Bingguang Xiao, Peijian Cao, Xingfu Wu, Chuyu Ye, Enhui Shen , Jie Qiu, Qian-Hao Zhu, Jiahua Xie, Xueping Zhou* and Longjiang Fan*. Regulation of Nicotine Biosynthesis by an Endogenous Target Mimicry of MicroRNA in Tobacco. Plant Physiology. 2015, 169(2): 1062-1071. IF: 6.841. Cited by: 32
12. Sang‐Ho Park^#, Fangfang Li^#, Justin Renaud, Wentao Shen, Yinzi Li, Lihua Guo, Hongguang Cui, Mark Sumarah and Aiming Wang*. NbEXPA1, an α‐Expansin, Is Plasmodesmata‐Specific and a Novel Host Factor for Potyviral Infection. The Plant Journal. 2017. 92(5): 846-861. IF: 5.901. Cited by: 7
13. Fangfang Li , Xiongbiao Xu, Xiuling Yang, Zhenghe Li and Xueping Zhou*. Identification of a cis-Acting Element Derived from Tomato Leaf Curl Yunnan Virus that Mediates the Replication of a Deficient Yeast Plasmid in Saccharomyces cerevisiae. Viruses. 2018, 10(10): 536. IF: 3.761. Cited by: 1
14. Fangfang Li, Yaqin Wang and Xueping Zhou*. SGS3 Cooperates with RDR6 in Triggering Geminivirus-Induced Gene Silencing and in Suppressing Geminivirus Infection in Nicotiana benthamiana. Viruses. 2017, 9 (9): 247. IF: 3.465. Cited by: 4
15. Xiaofei Cheng^#, Fangfang Li^#, Jianyu Cai, Wei Chen, Nan Zhao, Yuqiang Sun, Yushuang Guo, Xiuling Yang and Xiaoyun Wu*. Artificial TALE as a Convenient Protein Platform for Engineering Broad-Spectrum Resistance to Begomoviruses. Viruses. 2015, 7(8): 4772-4782. IF: 3.353. Cited by: 22
16. Bi Wang^#, Fangfang Li^#, Changjun Huang, Xiuling Yang, YajuanQian, Yan Xie and Xueping Zhou*. V2 of Tomato yellow leaf curl virus can suppress methylation-mediated transcriptional gene silencing in plant. Journal of General Virology. 2014, 95: 225-230. IF: 3.529. Cited by: 45