Lang Liu, Zhongming Zhang, Chenyang Wang, Fang Yan, Wenxian Sun, Xueping Zhou, Weiguo Miao*, Huanbin Zhou*, Developing guanine base editors for G-to-T editing in rice.
J Integr Plant Biol, 2024, https:// doi: 10.1111/jipb.13729
Abstract
Two guanine base editors created using an engineered N-methylpurine DNA glycosylase with CRISPR systems achieved targeted G-to-T editing with 4.94-12.50% efficiency in rice (Oryza sativa). The combined use of the DNA glycosylase and deaminases enabled co-editing of target guanines with adenines or cytosines.
J Integr Plant Biol,IF=9.3