Highlights

•Uptake and metabolism of a new pesticide cyetpyrafen in crops were firstly explored.

•Cyetpyrafen was mainly accumulated in roots likely through passive diffusion process.

•Thirteen new metabolites of cyetpyrafen were firstly identified in plants.

•Cyetpyrafen mainly underwent hydroxylation, hydrolysis and conjugation in crops.

•Phase I metabolites were estimated to be harmful/toxic toward nontarget organisms.

Environment International, IF: 13.352

Doi.org/10.1016/j.envint.2022.107522