刘文文，女，副研究员，硕士生导师，主要研究方向为植物病毒学。

2005年获得东北农业大学植物保护学学士学位，2008年获得东北农业大学植物病理学硕士学位，2013年获得中国农业科学院植物病理学博士学位。2013-2015在中国农业科学院植物保护研究所进行博士后研究工作，2014年获得中国农业科学院优秀博士后，2015年作为中国农业科学院青年英才计划D类人才进入植物保护研究所工作，并入选2017年北京市科技新星计划， 2019年为青年英才计划培育工程所级入选者。

长期从事植物病毒的介体昆虫传毒机制研究工作。主持国家自然基金面上等省部级项目4项，参加5项。植物病毒随着介体昆虫取食进入肠道，随后侵入肠道上皮细胞并释放到血淋巴，借助循环系统扩散到唾液腺，随着再次取食传播到健康植株上完成传毒。在病毒如何突破介体昆虫肠道和唾液腺等组织屏障以及抑制昆虫自噬逃避昆虫免疫攻击方面取得了一些研究进展。研究成果以第一或通讯作者在PLoS Pathogens、Trends in Microbiology、Molecular Plant Pathology、Molecular & Cellular Proteomics、Viruses和Current Opinion in Virology等期刊发表论文17篇。

联系电话：010-62815936；15201423729

E-mail：wwliu@ippcaas.cn；liuwenwen98@163.com

代表性性论文（#共同第一作者，*共同通讯作者）

1. Lu Zhang, Wenwen Liu*, Nan Wu, Hui Wang, Zhongkai Zhang, Yule Liu, Xifeng Wang*. Southern rice black-streaked dwarf virus induces incomplete autophagy for persistence in gut epithelial cells of its vector insect. PLoS Pathogens. 2023, 19(1): e1011134.

2. Wenwen Liu, Taiyun Wei*, Xifeng Wang*. Plant reoviruses hijack autophagy in insect vectors. Trends in Microbiology. 2023, 31(12): 1251-1261.

3. Lu Zhang, Wenwen Liu*, Xiaowan Zhang, Li Li, Xifeng Wang. Southern rice black-streaked dwarf virus hijacks SNARE complex of its insect vector for its effective transmission to rice. Molecular Plant Pathology, 2021, 22 (10): 1256-1270.

4. Beatriz Moya Fernández, Wenwen Liu*, Lu Zhang, Jamal-U-Ddin Hajano, Xifeng Wang. Interplay of rice stripe virus and rice black streaked dwarf virus during their acquisition and accumulation in insect vector. Viruses, 2021, 13: 1121. 

5. Lu Zhang, Wenwen Liu*, Xifeng Wang*. Immunofluorescent labeling of plant virus and insect vector proteins in hemipteran guts. Jove-Journal of Visualized Experiments, 2021, 171: e62605.

6. Wenwen Liu^#, Xiaowan Zhang^#, Nan Wu, Ren Ying Dang, Xifeng Wang. High diversity and functional complementation of alimentary canal microbiota ensure small brown planthopper to adapt different biogeographic environments. Frontiers in Microbiology, 2020, 10: 2953.

7. Jamal-U-Ddin Hajano, Ahmed Raza, Lu Zhang, Wenwen Liu*, Xifeng Wang. Ribavirin targets sugar transporter 6 to suppress acquisition and transmission of rice stripe tenuivirus by its vector Laodelphax striatellus. Pest Management Science, 2020, 76: 4086-4092.

8. Hui Wang, Nan Wu, Yan Liu, Jiban Kumar Kundu, Wenwen Liu*, Xifeng Wang*. Higher bacterial diversity of gut microbiota in different natural populations of leafhopper vector does not influence WDV transmission. Frontiers in Microbiology, 2019, 10: 1144.

9. Wenwen Liu, Jamal-U-Ddin Hajano, Xifeng Wang. New insights on the transmission mechanism of tenuiviruses by their vector insects. Current Opinion in Virology, 2018, 33: 13-17. 

10. Faliang Qin^#, Wenwen Liu^#, Nan Wu, Lu Zhang, Zhongkai Zhang, Xueping Zhou, Xifeng Wang. Invasion of midgut epithelial cells by a persistently transmitted virus is mediated by sugar transporter 6 in its insect vector. PLoS pathogens. 2018, 14: e1007201.

11. Peipei Zhang, Wenwen Liu*, Mengji Cao, Sebastien Massart*, Xifeng Wang. Two novel totiviruses in the white-backed planthopper, Sogatella furcifera. Journal of General Virology, 2018, 99: 710-716.

12. Wenwen Liu, Min Xin, Mengji Cao, Meng Qin, Shouqi Zhao, Xifeng Wang. Identifcation, characterization and full-length sequence analysis of a novel endornavirus in common sun?ower (Helianthus annuus L.). Journal of Integrative Agriculture, 2018, 17: 2281-2291.

13. Wenwen Liu, Stewart Gray, Yan Huo, Li Li, Taiyun Wei, Xifeng Wang. Proteomic analysis of interaction between a plant virus and its vector insect reveals new functions of a hemipteran cuticular protein, Molecular Cellular Proteomics, 2015, 14(8): 2229-2242.  

14. Yan Huo^#, Wenwen Liu^#, Fujie Zhang, Xiaoying Chen, Li Li, Qifei Liu, Yijun Zhou, Taiyun Wei, Rongxiang Fang, Xifeng Wang. Transovarial transmission of a plant virus is mediated by vitellogenin of its insect vector, PloS Pathogens, 2014, 10: e1003949.

15. 钟嘉怡, 李莉, 王锡锋, 刘文文*. 灰飞虱冠蛋白的基因克隆与表达分析. 植物保护. 2024, 50(02): 178-185.

16. 赵霞, 秦发亮, 刘文文*, 王锡锋. 灰飞虱VAP-B蛋白的抗体制备及体内外应用. 植物保护. 2022; 48(04): 220-225. 

17. 刘贝贝, 刘文文*, 王锡锋. 水稻条纹病毒对介体灰飞虱生长发育相关基因转录水平的影响. 植物病理学报, 2017, 47(01): 68-74.