任  杰，男，1986年5月生于河北保定，博士，副研究员。

2007本科毕业于南开大学化学系，2009年硕士毕业于天津大学药物化学系，2016年博士毕业于中国科学院天津工业生物技术研究所国家工业酶工程实验室；2016-2018年先后在北京化工大学软物质科学与工程高精尖创新中心做博士后工作并到德国汉堡工业大学做访问学者；2018年进入植物保护研究所工作。

主要研究方向是植物病害生物防治，从微生物中发掘鉴定抗菌促生的天然产物，利用合成生物学手段如关键酶的半理性设计改造、新型生物合成途径构建及代谢途径优化等，进一步提高活性产物产量，开发新型生物农药并推广应用。主持国家自然科学基金1项、国家重点研发子课题1项及北京自然科学基金项目1项。在ACS catalysis、Green Chemistry、ACS synthetic biology等期刊上发表研究论文30余篇，授权国家发明专利11项，转化横向8项。

联系方式

邮箱：renjie02@caas.cn   电话：15102266547

主持项目

1. 国家自然科学基金青年项目“基于甘氨酸调控的5-微生物细胞工厂的设计构建

3. 北京市自然科学基金青年项目，“甲酸生物利用途径中的羟甲基转移酶理性设计改造”

4. 中国农业科学院植物保护研究所基本科研业务费专项“基于优化有机蔬菜种植生态环境的生物防治技术集成与应用”

5. 横向项目“生物法合成氨基酸表面活性剂”

6. 横向项目“生物活性蛋白的高效制备方法”

7. 横向项目“植物生长调节剂的开发与应用”

8. 横向项目“一种由单一蛋白形成的智能水凝胶”

9. 横向项目“一种以甲醇/甲醛和葡萄糖为共底物生产1,3-丙二醇的方法”

发表文章

1. Ren, J. Yao, P. Yu S. Dong W. Chen Q. Feng J. Wu Q.Zhu D. An unprecedented effective enzymatic carboxylation of phenols. Acs Catalysis,2016, 6(2): 564-567.(IF:12.221)

2. Ren, J.*; Zhou, L.*; Wang, C. Lin, C. Li, Z. Zeng, A.-P., An Unnatural Pathway for Efficient 5-Aminolevulinic Acid Biosynthesis with Glycine from Glyoxylate Based on Retrobiosynthetic Design. ACS Synthetic Biology, 2018, 7 (12), 2750–2757. (IF:5.571)

3. Ren, J., Wang W., Nie J., Understanding and engineering glycine cleavage system and related metabolic pathways for C1-based biosynthesis [J]. One-Carbon Feedstocks for Sustainable Bioproduction, 2022, 273-98.

4. Ren, J. Dong, W. Yu, B. Wu, Q. Zhu, D., Synthesis of optically active alpha-bromohydrins via reduction of alpha-bromoacetophenone analogues catalyzed by an isolated carbonyl reductase. Tetrahedron-Asymmetry 2012,23 (6-7), 497-500. (IF:2.126)

5. Zhang, X. Li, M. Xu, Y.Ren, J. *; Zeng, A.-P. *, Quantitative study of H protein lipoylation of the glycine cleavage system and a strategy to increase its activity by co-expression of LplA. Journal of Biological Engineering, 2019,13 (1), 32. (IF:2.667)

6. Meng, H. Wang, C. Yuan, Q.Ren, J.*; Zeng, A.*; An Aldolase-Based New Pathway for Bioconversion of Formaldehyde and Ethanol into 1,3-Propanediol in Escherichia coli. ACS Synthetic Biology, 2021, 10, 799-809. (IF:5.571)

7. Zhang X., Nie, J., Zheng Y., Ren J.*, Zeng A.*; Activation and competition of lipoylation of H protein and its hydrolysis in a reaction cascade catalyzed by the multifunctional enzyme lipoate-protein ligase A; Biotechnology and Bioengineering; 2020.117(12):3677–3687. (IF:4.530)

8. Zhang H., Li Y., Nie J., Ren J.*, Zeng An-ping*; Structure-based dynamic analysis of the glycine cleavage system suggests key residues for control of a key reaction step. Communication Biology,2020,3 (1), 756-767. (IF:6.268)

9. Hong Y. *, Ren J. *, Zhang X., Wang W., Zeng A.-P. Quantitative analysis of glycine related metabolic pathways for one-carbon synthetic biology. Current Opinion in Biotechnology, 2019, 64:70-8(IF:8.083)

10. Wang C.*, Ren J.*, Zhou L., Li Z., Zeng A.-P., An aldolase-catalyzed new metabolic pathway for the assimilation of formaldehyde and methanol to synthesize 2-keto-4-hydroxybutyrate and 1,3-propanediol in Escherichia coli. ACS Synthetic Biology, 2019,8(11): 2483-2493(IF:5.571)

11. Zhou L.*, Ren J.*, Li Z., Nie J., Wang C., Zeng A.-P., Characterization and engineering of a Clostridium glycine riboswitch and its use to improve 5-aminolevulinic acid production in Escherichia coli. ACS Synthetic Biology, 2019,8(10): 2327-2335 (IF:5.571)

12. Zhang, X.Ren, J.*; Yao, P. Gong, R. Wang, M. Wu, Q. Zhu, D., Biochemical characterization and substrate profiling of a reversible 2,3-dihydroxybenzoic acid decarboxylase for biocatalytic Kolbe-Schmitt reaction. Enzyme and Microbial Technology, 2018, 113,37-43(IF:2.502)

13. Liu F*, Ren, J.*, Guo L. Desymmetric hydrolysis of prochiral imide for S-pregabalin synthesis by rationally designed d-hydantoinase [J]. Green Chemistry, 2022,24,4748-4753 (IF:9.800)

14. Li, G*. Ren, J*. Yao, P. Duan, Y. Zhang, H. Wu, Q. Feng, J. Lau, P. C. K. Zhu, D., Deracemization of 2-methyl-1,2,3,4-tetrahydroquinoline Using mutant cyclohexylamine oxidase obtained by Iterative Saturation Mutagenesis. Acs Catalysis 2014,4 (3), 903-908. (IF:12.221)

专利

1. 一种乙醛酸转氨酶介导的5-氨基乙酰丙酸生物合成途径（ZL 201810239867.X）

2. 一种H-蛋白突变体及其应用（ZL 202011383648.3）

3. 一种以甲醇/甲醛和葡萄糖为共底物生产1,3-丙二醇的方法（ZL201910006523.X ）

4. 一株昆虫病原线虫共生细菌及其应用 (ZL202110766306.8)

5. 一株具有广谱抑菌功能的昆虫病原线虫共生细菌及其应用（ZL202110766597.0）

6. 一株高产Xcn1的嗜线虫致病杆菌及其应用 (ZL202111147912.8)

7. 一种醛缩酶突变体及在生产1,3-丙二醇中的应用（ZL202110275116.6）

8.一种由单一蛋白形成的智能水凝胶（ ZL202010498594.9）

9. 一株有效提高Fcl29产量的改良菌株及改良方法（ZL202211372964.X）

10. 一种H-蛋白突变体（ZL 202111355274.9）

11. 一株苜蓿链霉菌及其应用 (202310216894.7)