宁约瑟，男。河南洛阳人，研究员，博士生导师。国家自然科学基金优秀青年基金获得者，入选农业农村部“杰出青年农业科学家”和中国农科院“农科英才领军人才B类”。现任国家农业生物安全中心副主任、植保生物技术中心主任、作物病原生物功能基因组研究创新团队首席科学家。兼任中国植物病理学会副秘书长。
2005年获河南农业大学农学专业学士学位，2011年获湖南农业大学作物遗传育种专业博士学位，2006年-2010年在教育部博士生访学计划资助下在中国科学院遗传与发育生物学研究所遗传学专业进行联合培养，2010年-2011年在美国俄亥俄州立大学植物病理系做访问博士研究生。2011年至今在中国农业科学院植物保护研究所植物病虫害综合治理全国重点实验室工作；2014年2月-2014年5月在美国俄亥俄州立大学植物病理系做访问学者。
主要从事水稻与稻瘟菌互作和水稻抗病性遗传学研究。先后主持国家自然科学基金优秀青年科学基金和国家重点研发计划等国家级课题7项。系统解析稻瘟菌效应蛋白与水稻靶标蛋白的互作机制，创制植物中首个E3泛素连接酶鉴定体系，揭示水稻核心E3泛素连接酶介导的抗稻瘟病新机制，为创制稻瘟病综合防控策略奠定了重要基础。研究结果先后发表SCI收录论文70余篇，总被引频次3800余次，H指数34。以第一/通讯作者（含共同）在 Developmental Cell 、 Genome Biology 、 Current Biology 、 Cell Reports 和 Science Bulletin 等杂志发表高水平SCI论文35篇。其中2项研究被 Faculty Opinions 推荐为新发现，4项研究分别被 Trends in Plant Science、Current Biology 、 Nature Food 和 Science Bulletin 杂志专题评论。受邀在 Annual Review of Plant Biology 和Trends in Plant Science 等杂志发表综述和评论文章。受邀在国际植物与微生物互作大会（IS-MPMI XVIII Congress）、第八届国际稻瘟病大会（The 8th International Rice Blast Conference）和国际动植物基因组大会（Plant & Animal Genome XXV Conference）等国际会议上做特邀报告。担任 Journal of Integrative Plant Biology 和 BMC Plant Biology 等SCI收录期刊编委。
E-mail: ningyuese@caas.cn
Website: https://www.researchgate.net/profile/Yuese_Ning
代表性论文(#共同第一作者，*共同通讯作者）
1. Xiao Xu (#), Xuetao Shi (#), Xiaoman You, Zeyun Hao, Ruyi Wang, Min Wang, Feng He, Shasha Peng, Hui Tao, Zheng Liu, Jisong Wang, Chongyang Zhang, Qin Feng, Weixun Wu, Guo-Liang Wang, and Yuese Ning (*). A pair of E3 ubiquitin ligases control immunity and flowering by targeting different ELF3 proteins in rice. Developmental Cell. DOI: 10.1016/j.devcel.2024.06.013, 2024
2. Chongyang Zhang, Hong Fang, Jisong Wang, Hui Tao, Debao Wang, Mengchao Qin, Feng He, Ruyi Wang, Guo-Liang Wang, and Yuese Ning (*). The rice E3 ubiquitin ligase-transcription factor module targets two trypsin inhibitors to enhance broad-spectrum disease resistance. Developmental Cell. DOI: 10.1016/j.devcel.2024.05.003, 2024
3. Xiaoman You, Shanshan Zhu, Haowen Sheng, Zheng Liu, Dan Wang, Min Wang, Xiao Xu, Feng He, Hong Fang, Fan Zhang, Debao Wang, Zeyun Hao, Ruyi Wang, Yinghui Xiao, Jianmin Wan, Guo-Liang Wang, and Yuese Ning (*). The rice peroxisomal receptor PEX5 negatively regulates resistance to rice blast fungus Magnaporthe oryzae. Cell Reports. 42(10):113315, 2023 Recommended in Faculty Opinions as New Finding and Good for Teaching
4. Ning Xiao (#), Yunyu Wu (#), Xiaoxiang Zhang (#), Zeyun Hao (#), Zichun Chen, Zefeng Yang,Yue Cai1, Ruyi Wang, Ling Yu, Zhiping Wang, Yue Lu, Wei Shi, Cunhong Pan, Yuhong Li, Changhai Zhou, Jianju Liu, Niansheng Huang, Guangqing Liu, Hongjuan Ji, Shuhao Zhu, Shuai Fang, Yuese Ning (*) and Aihong Li(*). Pijx confers broad-spectrum seedling and panicle blast resistance by promoting the degradation of ATP β subunit and OsRbohC-mediated ROS burst in rice. Molecular Plant . 16: 1832–1846, 2023
5. Wang Ruyi, Guo-Liang Wang (*) and Yuese Ning (*). Harnessing nanobodies to expand the recognition spectrum of plant NLRs for diverse pathogens. aBIOTECH .16; 4(3): 272-276, 2023
6. Xiaoman You, Yuese Ning (*), Guo-Liang Wang (*). Editing a rice CDP-DAG synthase confers broad-spectrum resistance. Trends in Plant Science. 28: 1344-1346, 2023
7. Fan Zhang (#), Min Wang (#), Guo-Liang Wang, Yuese Ning(*), Ruyi Wang (*). Insights into Metabolite Biosynthesis and Regulation in Rice Immune Signaling. Trends in Microbiology. 31: 225-228, 2023
8. Fan Zhang, Hong Fang, Min Wang, Feng He, Hui Tao, Ruyi Wang, Jiawei Long, Jiyang Wang, Guo-Liang Wang (*), Yuese Ning (*). APIP5 functions as a transcription factor and an RNA-binding protein to modulate cell death and immunity in rice. Nucleic Acids Research . 50: 5064–5079, 2022
Highlighted with a Research Highlight article in Trends in Plant Science https://doi.org/10.1016/j.tplants.2022.08.001
9. Zeyun Hao #), Jinfu Tian (#), Hong Fang (#), Liang Fang, Xiao Xu, Feng He, Shaoya Li, Wenya Xie, Qiang Du, Xiaoman You, Debao Wang, Qiuhong Chen, Ruyi Wang, Shimin Zuo, Meng Yuan, Guo-Liang Wang, Lanqin Xia (*), Yuese Ning (*). A VQ-motif- containing protein fine-tunes rice immunity and growth by a hierarchical regulatory mechanism. Cell Reports. 40: 111235, 2022
10. Ruyi Wang (#), Xiaoman You (#), Chongyang Zhang (#), Hong Fang (#), Min Wang, Fan Zhang, Houxiang Kang, Xiao Xu, Zheng Liu, Jiyang Wang, Qingzhen Zhao, Xuli Wang, Zeyun Hao, Feng He, Hui Tao, Debao Wang, Jisong Wang, Liang Fang, Mengchao Qin, Tianxiao Zhao, Pingping Zhang, Hefei Xing, Yunping Xiao, Wende Liu, Qi Xie, Guo-Liang Wang, Yuese Ning (*). An ORFeome of rice E3 ubiquitin ligases for global analysis of the ubiquitination interactome. Genome Biology . 23: 154, 2022
Recommended in Faculty Opinions as New Finding and Technical Advance
11. Xiaoman You (#), Fan Zhang (#), Zheng Liu, Min Wang, Xiao Xu, Feng He, Debao Wang, Ruyi Wang, Yiqin Wang, Guirong Wang, Chengcai Chu, Guo-Liang Wang, Yuese Ning (*). Rice catalase OsCATC is degraded by E3 ligase APIP6 to negatively regulate immunity. Plant Physiology. 190: 1095–1099, 2022
12. Hong Fang (#), Fan Zhang (#), Chongyang Zhang, Dan Wang, Shuangqian Shen, Feng He, Hui Tao, Ruyi Wang, Min Wang, Debao Wang, Xionglun Liu, Jie Luo, Guo-Liang Wang, Yuese Ning (*). Function of hydroxycinnamoyl transferases for the biosynthesis of phenolamides in rice resistance to Magnaporthe oryzae. Journal of Genetics and Genomics. 49: 776-786, 2022
13. Ruyi Wang (#), Xiao Xu (#), Guo-Liang Wang, Yuese Ning (*). Ubiquitination of susceptibility proteins modulates rice broad-spectrum resistance. Trends in Plant Science . 27: 322-324, 2022
14. Hong Fang (#), Shuangqian Shen (#), Dan Wang, Fan Zhang, Chongyang Zhang, Zixuan Wang, Qianqian Zhou, Ruyi Wang, Hui Tao, Feng He, Chenkun Yang, Meng Peng, Xinyu Jing, Zeyun Hao, Xionglun Liu, Jie Luo (*), Guo-Liang Wang (*), Yuese Ning(*). A monocot- specific hydroxycinnamoylputrescine gene cluster contributes to immunity and cell death in rice. Science Bulletin. 66: 2381–2393, 2021 Featured on the cover Highlighted with a Research Highlight article in Science Bulletin https://doi.org/10.1016/j.scib.2021.09.021
15. Ning Xiao (#), Cunhong Pan (#), Yuhong Li (#), Yunyu Wu, Yue Cai, Yue Lu, Ruyi Wang, Ling Yu, Wei Shi, Houxiang Kang, Zhaobing Zhu, Niansheng Huang, Xiaoxiang Zhang, Zichun Chen, Jianju Liu, Zefeng Yang (*), Yuese Ning(*), Aihong Li (*). Genomic insight into balancing high yield, good quality, and blast resistance of japonica rice. Genome Biology . 22:283, 2021 Highlighted with a Research Highlight article in Nature Food https://doi.org/10.1038/s43016-021-00410-w
16. Jiyang Wang (#), Ruyi Wang (#), Hong Fang, Chongyang Zhang, Fan Zhang, Zeyun Hao, Xiaoman You, Xuetao Shi, Chan Ho Park, Kangyu Hua, Feng He, Maria Bellizzi, Kieu Thi Xuan Vo, Jong-Seong Jeon, Yuese Ning (*), Guo-Liang Wang (*). Two VOZ transcription factors link an E3 ligase and an NLR immune receptor to modulate immunity in rice. Molecular Plant . 14: 253–266, 2021
17. Hui Tao, Xuetao Shi, Feng He, Dan Wang, Ning Xiao, Hong Fang, Ruyi Wang, Fan Zhang, Min Wang, Aihong Li, Xionglun Liu, Guo-Liang Wang (*), Yuese Ning (*). Engineering broad-spectrum disease-resistant rice by editing multiple susceptibility genes. Journal of Integrative Plant Biology . 63:1639–1648, 2021
18. Chongyang Zhang, Hong Fang, Xuetao Shi, Feng He, Ruyi Wang, Jiangbo Fan, Pengfei Bai, Jiyang Wang, Chan Ho Park, Maria Bellizzi, Xueping Zhou, Guo-Liang Wang (*), Yuese Ning (*). A fungal effector and a rice NLR protein have antagonistic effects on a Bowman–Birk trypsin inhibitor. Plant Biotechnology Journal .18: 2354–2363, 2020
19. Ruyi Wang (#), Feng He (#), Yuese Ning (*), Guo-Liang Wang (*). Fine-Tuning of RBOH-Mediated ROS Signaling in Plant Immunity. Trends in Plant Science .25: 1060-1062, 2020
20. Yiwen Deng (#), Yuese Ning (#), Dong-Lei Yang (#), Keran Zhai, Guo-Liang Wang (*), Zuhua He (*). Molecular Basis of Disease Resistance and Perspectives on Breeding Strategies for Resistance Improvement in Crops. Molecular Plant . 13: 1402–1419, 2020
21. Xiaoman You (#), Hong Fang (#), Ruyi Wang (#), Guo-Liang Wang, Yuese Ning (*). Phenylalanine ammonia lyases mediate broad-spectrum resistance to pathogens and insect pests in plants. Science Bulletin . 65: 1425-1427, 2020
22. Wei Li (#), Yiwen Deng (#), Yuese Ning (#), Zuhua He (*), Guo-Liang Wang (*). Exploiting Broad-Spectrum Disease Resistance in Crops: From Molecular Dissection to Breeding. Annual Review of Plant Biology . 71: 575–603, 2020
23. Ruyi Wang, Guo-Liang Wang (*), Yuese Ning (*). PALs: Emerging Key Players in Broad-Spectrum Disease Resistance. Trends in Plant Science . 24(9): 785-787, 2019
24. Chongyang Zhang (#), Zeyun Hao (#), Yuese Ning (*), Guo-Liang Wang (*). SINA E3 Ubiquitin Ligases: Versatile Moderators of Plant Growth and Stress Response. Molecular Plant . 12(5): 610-612, 2019
25. Yuese Ning, Guo-Liang Wang (*). Breeding plant broad-spectrum resistance without yield penalties. PNAS . 115(12): 2859-2861, 2018
26. Feng He, Fan Zhang, Wenxian Sun, Yuese Ning (*), Guo-Liang Wang (*). A Versatile Vector Toolkit for Functional Analysis of Rice Genes. Rice . 11(1): 27, 2018
27. Xuetao Shi (#), Yu Long (#), Feng He, Chongyang Zhang, Ruyi Wang, Ting Zhang, Wei Wu, Zeyun Hao, Yi Wang (*), Guo-Liang Wang (*), Yuese Ning (*). The fungal pathogen Magnaporthe oryzae suppresses innate immunity by modulating a host potassium channel. PLoS Pathogens . 14(1): e1006878, 2018
28. Yuese Ning, Wende Liu (*), Guo-Liang Wang (*). Balancing Immunity and Yield in Crop Plants. Trends in Plant Science . 22(12): 1069-1079, 2017
29. Qunen Liu (#), Yuese Ning (#), Yingxin Zhang (#), Ning Yu, Chunde Zhao, Xiaodeng Zhan, Weixun Wu, Daibo Chen, Xiangjin Wei, Guo-Liang Wang (*), Shihua Cheng (*), Liyong Cao (*). OsCUL3a Negatively Regulates Cell Death and Immunity by Degrading OsNPR1 in Rice. Plant Cell . 29(2): 345-359, 2017
30. Ruyi Wang (#), Yuese Ning (#), Xuetao Shi, Feng He, Chongyang Zhang, Jiangbo Fan, Nan Jiang, Yu Zhang, Ting Zhang, Yajun Hu, Maria Bellizzi, Guo-Liang Wang (*). Immunity to Rice Blast Disease by Suppression of Effector-Triggered Necrosis. Current Biology . 26: 2399–2411, 2016
Highlighted with a Dispatch article in Current Biology http://dx.doi.org/10.1016/j.cub.2016.08.038
31. Yuese Ning (#), Ruyi Wang (#), Xuetao Shi, Xueping Zhou, Guo-Liang Wang (*). A Layered Defense Strategy Mediated by Rice E3 Ubiquitin Ligases against Diverse Pathogens. Molecular Plant . 9: 1096–1098, 2016
32. Yuese Ning (#), Xuetao Shi (#), Ruyi Wang (#), Jiangbo Fan, Chan Ho Park, Chongyang Zhang, Ting Zhang, Xinhao Ouyang, Shigui Li, Guo-Liang Wang (*). OsELF3-2, an ortholog of Arabidopsis ELF3, interacts with the E3 ligase APIP6 and negatively regulates immunity against Magnaporthe oryzae in rice. Molecular Plant . 8: 1679-1682, 2015
33. Hao Zhang, Jinling Liu, Feng He, Zhilong Wang, Yuese Ning (*), and Guo-Liang Wang (*). OsHUB1 and OsHUB2 interact with SPIN6 and form homo- and hetero-dimers in rice. Plant Signaling & Behavior 10:8, e1039212, 2015
34. Jinling Liu (#), Wei Li (#), Yuese Ning (#), Gautam Shirsekar, Yuhui Cai, Xuli Wang, Liangying Dai, Zhilong Wang, Wende Liu, Guo-Liang Wang (*). The U-box E3 Ligase SPL11/PUB13 Is a Convergence Point of Defense and Flowering Signaling in Plants. Plant Physiology . 160: 28-37, 2012
35. Yuese Ning, Chachawan Jantasuriyarat, Qingzhen Zhao, Huawei Zhang, Songbiao Chen, Jinling Liu, Lijing Liu, Sanyuan Tang, Chan Ho Park, Xuejun Wang, Xionglun Liu, Liangying Dai, Qi Xie (*), Guo-Liang Wang (*). The SINA E3 ligase OsDIS1 Negatively Regulates Drought Response in Rice. Plant Physiology. 157: 242-255, 2011 2011
