李广悦，男，1983年生，研究员，博士生导师，入选中国农业科学院“杰出青年英才”，现任中国农业科学院“植物病害生物防治”创新团队首席科学家。主要从事微生物源农药的研究工作，成功开发了泽纳菌肽、害虫抗性抑制剂等产品；在JACS、ACS Catalysis、Chemical Science等国内外学术期刊上发表研究论文60多篇；第一发明人获得国家发明专利5项；获省部一等奖和二等奖各一项。主持国家重点研发项目课题、国家自然基金面上项目、青年项目以及与企业合作的横向项目等；以第一负责人实现横向成果转化1000万元；研提的科学命题入选“2022中国农业农村重大科学命题”，研究成果入选2025年度农业“火花技术”。

联系邮箱：liguangyue@caas.cn; liguangyue1983@163.com

已发表文章：

1. Duan, J.; Yuan, B.; Jia, F.; Li, X.; Chen, C.; Li, G*., Development of an efficient and seamless genetic manipulation method for Xenorhabdus and its application for enhancing the production of Fabclavines. J. Agric. Food Chem. 2024, 72 (1), 274-283.  

2. Qin, Y#.; Jia, F#.; Zheng, X.; Li, X.; Duan, J.; Li, B.; Shen, H.; Yang, X.; Ren, J.; Li, G*. Enhancing the Production of Xenocoumacin 1 in Xenorhabdus nematophila CB6 by a Combinatorial Engineering Strategy. J. Agric. Food Chem. 2023, 71(23), 8959–8968.

3. Li, B.; Yuan, B.; Duan, J.; Qin, Y.; Shen, H.; Ren, J.; Francis, F.; Chen, M.; Li, G*., Identification of Fcl-29 as an Effective Antifungal Natural Product against Fusarium graminearum and Combinatorial Engineering Strategy for Improving Its Yield. J. Agric. Food Chem. 2023, 71 (14), 5554-5564.

4. Dong, Y^#.; Li, T^#.; Zhang, S^#.; Sanchis, J.; Yin, H.; Ren, J.; Sheng, X*.; Li, G*.; Reetz, M. T*. Biocatalytic Baeyer-Villiger Reactions: Uncovering the Source of Regioselectivity at Each Evolutionary Stage of a Mutant with Scrutiny of Fleeting Chiral Intermediates. ACS Catalysis 2022, 12, 3669-3680.

5. Jiaqi Duan, Beibei Li, Youcai Qin, Yijie Dong, Jie Ren and Guangyue Li*. Recent progress in directed evolution of stereoselective monoamine oxidases. Bioresources and Bioprocessing . 2019, 6: 1-11.

6. Li, G.; Dong, Y.; Reetz, M. T*. Can Machine Learning Revolutionize Directed Evolution of Selective Enzymes? Adv. Synth. Catal. 2019, 361, 2377 – 2386. 

7. Li, G.; Garcia-Borràs, M.; Fürst, M. J. L. J.; Ilie, A.; Fraaije, M. W.; Houk, K. N*.; Reetz, M. T*. Overriding Traditional Electronic Effects in Biocatalytic Baeyer-Villiger Reactions by Directed Evolution. J. Am. Chem. Soc. 2018, 140, 10464−10472.

8. Peiyuan Yao, Peiqian Cong, Rui Gong, Jinlong Li, Guangyue Li, Jie Ren, Jinhui Feng, Jianping Lin, Peter C. K. Lau,* Qiaqing Wu,* and Dunming Zhu*.Biocatalytic Route to Chiral 2-Substituted-1, 2, 3, 4-tetrahydroquinolines Using Cyclohexylamine Oxidase Muteins. ACS Catalysis. 2018, 8, 1648-1652..

9. Li, G^#.; Yao, P^#.; Gong, R^#.; Li, J.; Liu, P.; Lonsdale, R.; Wu, Q.; Lin, J*.; Zhu, D*.; Reetz, M. T*. Simultaneous engineering of an enzyme’s entrance tunnel and active site: The case of monoamine oxidase MAO-N. Chemical Science. 2017, 8, 4093-4099.

10. Guangyue Li, Miguel A. Maria-Solano, Adrian Romero-Rivera, Sílvia Osuna* and Manfred T. Reetz*. Inducing High Activity of a Thermophilic Enzyme at Ambient Temperatures by Directed Evolution. Chemical Communications. 2017, 53，9454-9457. 

11. Guangyue Li^#, Hui Zhang^#, Zhoutong Sun, Xinqi Liu and Manfred T. Reetz*. Multiparameter Optimization in Directed Evolution: Engineering Thermostability, Enantioselectivity, and Activity of an Epoxide Hydrolase. ACS Catalysis . 2016, 6(6), 3679−3687.