韩兰芝，女，山东郓城县人，博士，研究员，博士生导师。兼任中国植物保护学会生物安全专业委会主任委员，农业农村部转基因生物安全评价（环境）重点实验室副主任。
1999年获青岛农业大学植物保护专业学士学位，2004年获南京农业大学农业昆虫与害虫防治专业博士学位，2007年6月从中国农业科学院植物保护研究所生物安全专业博士后流动站出站并留所工作至今。2012年11月-2013年12月在美国田纳西大学昆虫学专业进行访学合作研究。
韩兰芝研究员长期从事水稻害虫灾变机制与绿色防控技术及转基因作物环境安全评价研究，在二化螟灾变机制与绿色防控技术研发、靶标害虫对Bt和RNAi作物抗性机制与治理策略、非靶标生物生态效应等方面均积累了丰富的工作经验。主持国家自然科学基金项目 (30800723,31572336, 32272546) 3项、农业生物育种重大项目-环境安全评价技术创新与应用支撑体系建设项目课题（2023ZD0406204）1项和国家标准项目（20251013）1项，主持转基因生物新品种培育重大专项重点课题(2009ZX08011-007B)和子课题“RNAi转基因植物环境安全评价技术（2018ZX0801101B-002）各1项。作为主要科研骨干承担转基因生物新品种培育重大专项课题(2016ZX08011-001, 2014ZX08011-001, 2013ZX08011-001, 2011ZX08011-001, 2008ZX08011-001)、农业部财政专项-农产品质量安全项目等课题。以第一/通讯作者在Current Opinion in Insect Science,Journal of Pest Science, International Journal of Biological Macromolecules, Journal of Agricultural and Food Chemistry, Applied Environmental and Microbiology, Pest Management Science等国际期刊和国内核心期刊共发表学术论文60余篇，以第一作者获得授权的国家发明专利5项，编制国家标准6项，编写《转基因生物安全》等书籍4部。
联系方式：
Tel: 010-62819620; Email: hanlanzhi@caas.cn
作为第一/通讯作者（*）发表的代表性论文：
1. Chen G#, Chen JJ#, Wen N#, Liu LP, Yang XX, Li F*, Han LZ*. 2025. Using transcriptome diversity to evaluate the off-target effects of miRNA-mediated transgenic rice. Journal of Agriculture and Food Chemistry. 73: 16573-16583.
2. Chen G#, Li QW#, Zhang C, Zhao WX, Jurat-Fuentes, Zhou XG, Chen FJ, Yang XW*, Han LZ*. 2024. Synergism of Cry1Ca toxicity by gut resident Enterococcus spp. in the rice stem borer, Chilo suppressalis. International Journal of Biological Macromolecules. 257: 128654.
3. Zhou QL, Han LZ, Li YH, Li J, Yang XW. 2023. Neutral dietary effects of two microRNAs, Csu-Novel-260 and Csu-Mir-14, on the non-target arthropod Folsomia candida. Plants 2023, 12(9): 1885.
4. Chen G, Li QW, Yang XX, Li YH, Liu WW, Chen FJ, Han LZ*. 2023. Comparison of the co‑occurrence patterns of the gut microbial community between Bt-susceptible and Bt-resistant strains of the rice stem borer, Chilo suppressalis. Journal of Pest Science. 96: 299-315.
5. Zhou YF, Huang CM, Chen Y, Han LZ, Xie JJ, Chen XP*. 2023. Sensitivities of fall armyworm (Spodoptera frugiperda) populations in different regions of China to four Bt proteins. Agronomy. 13: 2415.
6. Wang HL, Zhang C, Chen G, Li YH, Yang XW*, Han LZ*, Peng YF. 2022. Downregulation of the CsABCC2 gene is associated with Cry1C resistance in the striped stem borer Chilo suppressalis. Pesticide Biochemistry and Physiology 184: 105119.
7. Wang YY, Liu QS, Song XY, Yang XW, Han LZ, Romeis J, Li YH. 2022. Unintended changes in transgenic maize cause no nontarget effects. Plants People Planet. 4: 392-402.
8. Chen JJ, Wang HH, Yang XX, Chen G, Du LX, Chen H, Li YH, Peng YF, Han LZ*. 2021. Consumption of miRNA-mediated insect-resistant transgenic rice pollen does not harm Apis mellifera adults. Journal of Agricultural and Food Chemistry, 69, 14: 4234-4242.
9. Wen N, Chen JJ, Chen G, Du LX, Chen H, Li YH, Peng YF, Yang XW*, Han LZ*. 2021. The overexpression of insect endogenous microRNA in transgenic rice inhibits the pupation of Chilo suppressalis and Cnaphalocrocis medinalis. Pest Management Science, 77(9): 3990-3999.
10. Wu N, Shi WC, Liu WW, Gao Z, Han LZ*, Wang X*, 2021. Differential impact of Bt-transgenic rice plantings on bacterial community in three niches over consecutive years, Ecotoxicology and Environmental Safety, 223: 112569.
11. Chen G, Wang YH, Liu YM, Chen FJ, Han LZ*. 2020. Differences in midgut transcriptomes between resistant and susceptible strains of Chilo suppressalis to Cry1C toxin. BMC Genomics, 21: 634-653.
12. Zhang C, Luo J, Chen G, Han LZ*, Peng YF. 2019. A new method to obtain isofemale lines for monitoring Chilo suppressalis resistance to Bt toxin. Journal of Invertebrate Pathology, 163, 8-10.
13. Du LX, Chen G, Han LZ*, Peng YF. 2019. Cadherin CsCad plays differential functional roles in Cry1Ab and Cry1C intoxication in Chilo suppressalis. Scientific Report, 9: 8507.
14. Zhou YC, Jia BT, Han LZ*, Peng YF. 2019. A morphological and functional characterization of isolated stem cells from the midgut of Chilo suppressalis larvae. Journal of Asia-Pacific Entomology, 22(3): 982-989.
15. Tang H, Chen G, Chen FJ, Han LZ*, Peng YF. 2018. Development and relative fitness of Cry1C resistance in Chilo suppressalis. Pest Manage Science, 74：590-597.
16. Wang XY, Du LX, Liu CX, Gong L, Han LZ*, Peng YF. 2017. RNAi in the striped stem borer, Chilo suppressalis, establishes a functional role for aminopeptidase N in Cry1Ab intoxication. Journal of Invertebrate Pathology, 143: 1-10.
17. Han LZ*, Jiang XF, Peng YF. 2016. Potential resistance management for the sustainable use of insect-resistant genetically modified corn and rice in China. Current Opinion in Insect Science. 15:139-143.
18. Li B, Xu YY, Han C, Han LZ*, Hou ML, Peng YF. 2015. Chilo suppressalis and Sesamia inferens display different susceptibility responses to Cry1A insecticidal proteins. Pest Management Science, 71: 1433-1440.
19. Liu YD, Han LZ, Hou ML. 2015. Loss of Genetic variation in laboratory colonies of Chilo suppressalis (Lepidoptera: Crambidae) revealed by mitochondrial and microsatellite DNA markers. Environal Entomology, 44(1): 73-80.
20. Gong L, Wang HD, Qi JW, Han LZ, Hu MY, Jurat-Fuentes. 2015. Homologs to Cry toxin receptor genes in a de novo transcriptome and their altered expression in resistant Spodoptera litura larvae. Journal of Invertebrate Pathology, 129, 1-6.
21. Han LZ*, Han C, Jurat-Fuentes JL,Hou ML, Peng YF. 2014. Binding site concentration explains the differential susceptibility of Chilo suppressalis and Sesamia inferens to cry1A-producing rice. Applied and Environmental Microbiology, 80 (16): 5134-5140.
22. Wang YN, Ke KQ, Li YH, Han LZ, Liu YM, Hua HX, Peng YF, 2014. Comparison of three transgenic Bt rice lines for insecticidal protein expression and resistance against a target pest, Chilo suppressalis (Lepidoptera: Crambidae). Insect Science, 11(1):78-87.
23. Wang YN, Zhang L, Li YH, Han LZ, Liu YM, Zhu Z, Wang F, Peng YF, 2014. Expression of Cry1Ab protein in a marker-free transgenic Bt rice line and its efficacy in controlling a target pest, Chilo suppressalis (Lepidoptera: Crambidae). Environmental Entomology, 43(2): 528-536.
24. Li YH, Hu L, Romeis J, Wang YN, Han LZ, Chen XP, Peng YF. 2014. Use of an artificial diet system to study the toxicity of gut-active insecticidal compounds on larvae of the green lacewing Chrysoperla sinica. Biological Control, 69: 45-51.
25. Han LZ, Li SB, Peng YF, Hou ML. 2012. New artificial diet for continuous rearing of Chilo suppressalis. Ann. Entomol. Soc. Am. 2012, 105(2): 253-258.
