李.方.方，女，博士，研究员，硕士生/博士生导师。2009年本科毕业于南京农业大学植物保护专业，2014年博士毕业于浙江大学植物病理学专业。2014-2015年在浙江大学作物科学研究所开展博士后研究工作；2015-2018年在加拿大农业与农业食品部，伦敦研究与发展中心，先后从事博士后、助理研究员工作；2018年8月成为中国农业科学院植物保护研究所‘青年英才计划引进工程’入选者；2019年4月入选‘国家海外高层次引进人才’和中国农业科学院领军B类“农科英才。
李.方.方目前在植物病虫害生物学国家重点实验室-植物与病毒互作组开展研究工作。主要从事植物与病毒的互作研究，以烟草、拟南芥、番茄和油菜为植物实验材料，以世界上危害最为严重、种类最多的两类植物病毒：双生病毒科病毒和马铃薯Y科病毒为研究对象，开展寄主植物与病毒的互作(双生病毒科病毒与寄主烟草和番茄的互作研究；芜菁花叶病毒与寄主拟南芥、烟草和油菜的互作研究)方面的工作。涉及的寄主途径包含DNA甲基化、RNA沉默、RNA降解、细胞自噬、泛素-26S蛋白酶体降解系统等。围绕着植物与病毒互作的机制，解析植物病毒致病的机制，进一步挖掘出新型有效的抗病基因。近几年部分研究结果以通讯作者/第一作者身份在Nature Communications （1篇）、Trends in Microbiology（1篇）、Molecular Plant（1篇）、PLoS Pathogens（3篇）、New Phytologist（3篇）、Plant Physiology（1篇）、The Plant Journal（1篇）等专业杂志发表SCI收录论文22篇，累计影响因子超142，他引次数超300次；以参与作者身份在Trends in Plant Science、The Plant Cell、Frontiers in Plant Science等专业杂志上发表SCI收录论文8篇；以第一完成人授权专利4项；研究成果获2020年中国农业科学院科学技术成果奖（第一完成人，青年科技创新奖）；担任Frontiers in Microbiology、Frontiers in Plant Science等杂志的学术编委。
联系电话：13641100481
E-mail: lifangfang@caas.cn 或 elva1988@163.com
代表性论文（#共同第一作者，*共同通讯作者）
[1] Yongsen Cao, Huanbin Zhou, Xueping Zhou, Fangfang Li*. Conferring resistance to plant RNA viruses with the CRISPR/CasRx system.Virologica Sinica (2021), https://doi.org/10.1007/s12250-020-00338-8
[2] Fangfang Li*, Mingzhen Zhang, Changwei Zhang, Xueping Zhou. Nuclear autophagy degrades a geminivirus nuclear protein to restrict viral infection in Solanaceous plants. New Phytologist (2020), 225(4): 1746-1761.
[3] Fangfang Li#, Changwei Zhang#, Ziwei Tang, Lingrui Zhang, Zhaoji Dai, Shanwu Lyu, Yinzi Li, Xilin Hou, Mark Bernards, Aiming Wang*. A plant RNA virus activates selective autophagy in a UPR-dependent manner to promote virus infection. New Phytologist (2020),10.1111/nph.16716.
[4] Hao Li#, Fangfang Li#,*, Mingzhen Zhang, Pan Gong, Xueping Zhou*. Dynamic subcellular localization, accumulation, and interactions of proteins from tomato yellow leaf curl China virus and its associated betasatellite. Frontiers in Plant Science (2020),11:840.
[5] Wanqin He #, Jiayu Wu #, Yiyi Ren, Xueping Zhou, Songbai Zhang, Yajuan Qian , Fangfang Li*, Jianxiang Wu*. Highly sensitive serological approaches for Pepino mosaic virus detection. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) (2020), 21(10):811-822.
[6] Yongsen Cao, Huanbin Zhou, Xueping Zhou*, Fangfang Li*. Control of plant viruses by CRISPR/Cas system-mediated adaptive immunity. Frontiers in Microbiology (2020), 11:593700
[7] Fangfang Li#, Xiongbiao Xu#, Zhenghe Li, Yaqin Wang*, Xueping Zhou. Identification of yeast factors involved in the replication of mungbeang yellow mosaic India virus using yeast temperature-sensitive mutants. Virologica Sinica (2020), 35: 120-123.
[8] Fangfang Li, Aiming Wang*. RNA-targeted antiviral immunity: more than just RNA silencing. Trends in Microbiology (2019), 27(9):792-805.
[9] Fangfang Li, Wende Liu, Xueping Zhou*. Pivoting plant immunity from theory to the field. Science China-Life Sciences (2019), 62(11):1539-1542.
[10] Fangfang Li, Changwei Zhang, Yinzi Li, Guanwei Wu, Xilin Hou, Xueping Zhou, Aiming Wang*. Beclin1 restricts RNA virus infection in plants through suppression and degradation of the viral polymerase. Nature Communications (2018), 28,9(1):1268.
[11] Fangfang Li, Xiuling Yang, David M Bisaro, Xueping Zhou*. The βC1 protein of geminivirus-betasatellite complexes: A target and repressor of host defenses. Molecular Plant (2018), 11:1424-1426.
[12] Fangfang Li, Aiming Wang*. RNA decay is an antiviral defense in plants that is counteracted by viral RNA silencing suppressors. PLoS pathogens (2018), 14.8: e1007228.
[13] Fangfang Li, Xiongbiao Xu, Xiuling Yang, Zhenghe Li, Xueping Zhou*. Identification of a cis-acting element derived from tomato leaf curl Yunnan virus that mediates the replication of a deficient yeast plasmid in Saccharomyces cerevisiae. Viruses (2018), 10(10): 536.
[14] Fangfang Li, Nan Zhao, Zhenghe Li, Xiongbiao Xu, Yaqin Wang, Xiuling Yang, Shu-Sheng Liu, Aiming Wang, Xueping Zhou*. A calmodulin-like protein suppresses RNA silencing and promotes geminivirus infection by degrading SGS3 via the autophagy pathway in Nicotiana benthamiana. PLoS Pathogens (2017), 13(2): e1006213.
[15] Sang‐Ho Park#, Fangfang Li#, Justin Renaud, Wentao Shen, Yinzi Li, Lihua Guo, Hongguang Cui, Mark Sumarah, Aiming Wang*. NbEXPA1, an α-expansin, is plasmodesmata-specific and a novel host factor for potyviral infection. The Plant Journal (2017), 2(5): 846-861.
[16] Fangfang Li, Yaqin Wang, Xueping Zhou*. SGS3 cooperates with RDR6 in triggering geminivirus-induced gene silencing and in suppressing geminivirus infection in Nicotiana benthamiana. Viruses (2017), 9 (9):247.
[17] Fangfang Li#, Xiongbiao Xu#, Changjun Huang, Zhouhang Gu, Linge Cao, Tao Hu, Ming Ding, Zhenghe Li, Xueping Zhou*. The AC5 protein encoded by mungbean yellow mosaic India virus is a pathogenicity determinant that suppresses RNA silencing‐based antiviral defenses. New Phytologist (2015), 208(2):555-569.
[18] Fangfang Li#, Weidi Wang#, Nan Zhao, Bingguang Xiao, Peijian Cao, Xingfu Wu, Chuyu Ye, Enhui Shen, Jie Qiu, Qian-Hao Zhu, Jiahua Xie, Xueping Zhou*, Longjiang Fan*. Regulation of nicotine biosynthesis by an endogenous target mimicry of microRNA in tobacco. Plant Physiology (2015), 169(2): 1062-1071.
[19] Xiaofei Cheng1#*, Fangfang Li1#, Jianyu Cai, Wei Chen, Nan Zhao, Yuqiang Sun, Yushuang Guo, Xiuling Yang, Xiaoyun Wu*. Artificial TALE as a convenient protein platform for engineering broad-spectrum resistance to begomoviruses. Viruses (2015), 7(8): 4772-4782.
[20] Fangfang Li, Changjun Huang, Zhenghe Li, Xueping Zhou*. Suppression of RNA silencing by a plant DNA virus satellite requires a host calmodulin-like protein to repress RDR6 expression. PLoS Pathogens (2014), 10: e1003921.
