张艳艳，女，1982年9月出生，山东聊城人，主要研究方向为微生物天然产物农药生物合成调控，副研究员。
2006年获得烟台大学生物技术专业学士学位，2009年获得山东大学微生物学硕士学位，2014年获得中国科学院微生物研究所遗传学博士学位。2014-2016在中国农业科学院植物保护研究所进行博士后研究工作，2016年至今在中国农业科学院植物保护研究所植物病虫害生物学国家重点实验室工作，一直从事放线菌源天然产物农药生物合成调控的研究，先后主持国家自然科学基金课题2项。
以具有重要植物保护应用价值的链霉菌源微生物农药如米尔贝霉素，尼莫克丁和五谷丰素等为主要研究对象，利用遗传学，生物化学和分子生物学及合成生物学等手段解析其途径特异性和全局性的生物合成调控机制，构建生物合成调控网络；在此基础上，选择有效的代谢改造靶点，从根本上解决限制菌株产量提高的瓶颈，为获得具有自主知识产权的微生物农药高产工程菌株和满足产业发展的迫切需求奠定基础。研究成果以第一或通讯作者在Molecular Microbiology, Science China Life Sciences, Microbial Cell Factories, Frontiers in Microbiology和Frontiers in bioengineering and biotechnology等期刊上发表SCI论文8篇。授权国家发明专利1项。获省级科学技术一等奖2项。
联系电话：010-62810155
E-mail: yyzhang@ippcaas.cn
发表论文如下：
1、Yang Xue, Zhang Yanyan#*, Li Shanshan, Ye Lan, Wang Xiangjing, Xiang Wensheng*. 2022. SspH, a Novel HATPase Family Regulator, Controls Antibiotic Biosynthesis in Streptomyces. Antibiotics (Basel). 11(5): 538
2、Ye Lan, Zhang Yanyan#*, Li Shanshan, He Hairong, Ai Guomin, Wang Xiangjing, Xiang Wensheng*. 2022. Transcriptome-guided identification of a four-component system, SbrH1-R, that modulates milbemycin biosynthesis by influencing gene cluster expression, precursor supply, and antibiotic efflux. Synthetic and Systems Biotechnology. 7(2): 705-717.
3、Liu Hui#, Zhang Yanyan#*, Li Shanshan, Wang Jiabin, Wang Xiangjing, Xiang Wensheng*. 2020. Elucidation of the Activation Pathways of ScyA1/ScyR1，an Aco/ArpA-Like System That Regulates the Expression of Nemadectin and Other Secondary Metabolic Biosynthetic Genes. Frontiers in Bioengineering and Biotechnology. (8):589730.
4、Zhang Yanyan, He Hairong, Liu Hui, Wang Haiyan, Wang Xiangjing, Xiang, Wensheng*. 2016. Characterization of a pathway-specific activator of milbemycin biosynthesis and improved milbemycin production by its overexpression in Streptomyces bingchenggensis. Microbial Cell Factories, 15(1).
5、He Hairong, Ye Lan, Li Chuang, Liu Hui, Wang Haiyan, Guo Xiaowei, Wang Xiangjing, Zhang Yanyan*, Xiang Wensheng*. 2018. SbbR/SbbA, an important ArpA/AfsA-like system, regulates milbemycin production in Streptomyces bingchenggensis. Frontiers in Microbiology. 23(9):1064.
6、Li Chuang, He Hairong, Wang Jiabin, Liu Hui, Wang Haiyan, Zhu Yajie, Wang Xiangjing, Zhang Yanyan*, Xiang Wensheng*. 2019. Characterization of a LAL-type regulator NemR in nemadectin biosynthesis and its application for increasing nemadectin production in Streptomyces cyaneogriseus. Science China Life Sciences. 62(3):394-405.
7、Zou Zhengzhong, Du Deyao, Zhang Yanyan, Zhang Jihui, Niu Guoqing Tan Huarong*. 2014. A γ-butyrolactone-sensing activator/repressor, JadR3, controls a regulatory mini-network for jadomycin biosynthesis. Molecular Microbiology. 94(3):490-505.
8、Zhang Yanyan#, Pan Guohui#，Zou Zhengzhong, Fan Keqiang, Yang Keqian*，Tan Huarong*. 2013. JadR*-mediated feed-forward regulation of cofactor supply in jadomycin biosynthesis. Molecular Microbiology. 94(4):884-897.
9、Zhang Yanyan, Zou Zhengzhong, Niu Guoqing, Tan Huarong*. 2013. jadR* and jadR2 act synergistically to repress jadomycin biosynthesis. Science China Life Sciences.
